Which agent is a nonsedating antihistamine
In other embodiments, the non-sedating or second and third generation antihistamine injectable formulations are therapeutically equivalent to diphenhydramine injectable formulations and/or are more effective than placebo. These cells, in turn, release histamine, serotonin, leukotrienes, and prostaglandins, and induce a range of signs and symptoms, such as facial flushing, urticaria (hives), edema, pruritus, broncho-constriction, cough, cardiac arrhythmias, hypotension, nausea, vomiting, and diarrhea.
In other embodiments, a non-sedating antihistamine injectable composition is delivered by an autoinjector.1. Cutaneous manifestations are most common, with urticaria and angioedema present in 88% or more of patients experiencing acute allergic reactions.
These include urticaria (hives), atopic dermatitis (AD), facial eczema due to nasal allergies/hay fever, as well as bug bites. Tom observes that in pediatric patients, antihistamines should be chosen so as to minimize potential adverse events, such as drowsiness, which could interfere with school or activities.Antihistamines are known to quell inflammation and are common over-the-counter remedies for several dermatologic conditions.But like many other agents, antihistamines are most effective under a particular set of circumstances.Sedation and impairment of performance are concerns when sedating antihistamines are used, but these adverse effects may diminish after 1-2 weeks of therapy.Many patients find that pruritus is less troublesome during the day but is maximized at night, when there are fewer distractions.
Topical diphenhydramine is sometimes used especially on patients in hospice.